Phospho-IRF3 (S386) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-IRF3 (S386) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-IRF3 (S386) Antibody detects endogenous levels of total Phospho-IRF3 (S386). Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. |
| Immunogen | Immunogen: A synthesized peptide derived from human Phospho-IRF3 (S386) |
| Other Names | [IRF3; Interferon regulatory factor 3] |
| Gene, Accession # | [IRF3], Gene ID: 3661, NCBI: NP_001184051.1, UniProt: Q14653 |
| Catalog # | MBS4750307 |
| Price | $335 |
| Order / More Info | Phospho-IRF3 (S386) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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