Description | Specificity: Mouse CD40, Mr 45-50 kDa. CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs.^1-5 CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM^+IgD^lo B220^lo) express intermediate levels of CD40, whereas mature B cells (IgM^+IgD^hi B220^hi) express high levels.^4 CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 r |
Product Specific References | 1. Santos-Argumedo, L., J. Gordon, A.W. Heath, and M. Howard. 1994. Cell. Immunol. 156:272.2. Heath, A.W., W.W. Wu, and M.C. Howard. 1994. Eur. J. Immunol. 24:1828.3. Hasbold, J., C. Johnson-Leger, C.J. Atkins, E.A. Clark, and G.G. Klaus. 1994. Eur. J. Immunol. 24:1835.4. Grandien, A., A. Bras, and C. Martinez. 1996. Scand. J. Immunol. 43:47.5. Noelle, R.J., J.A. Ledbetter, and A. Aruffo. 1994. Immunol. Today 13:431.6. Clark, E.A., and J.A. Ledbetter. 1994. Nature 367:425. |