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Antigenic Specificity | IRF-3 (Ab-396) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total IRF-3 protein. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.394-398(H-I-S-N-S) derived from Human IRF-3. |
Other Names | [interferon regulatory factor 3,] |
Gene, Accession # | [IRF-3], Gene ID: 396656, NCBI: NP_998935.1 |
Catalog # | MBS9405485 |
Price | $200, $255 |
Order / More Info | IRF-3 (Ab-396) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |