Vinculin Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Vinculin antibody, protein, ELISA kits.
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| Antigenic Specificity | Vinculin |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat, rabbit, chicken |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Biotin-Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist. Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5). |
| Immunogen | Immunogen: Biotin-Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin. Buffer: Biotin-Vinculin Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [CMD1W; CMH15; Metavinculin; MVCL; vinculin], [VCL; VCL; MV; MVCL; CMD1W; CMH15; HEL114; MV] |
| Gene, Accession # | [VCL], Gene ID: 7414, NCBI: NP_003364, UniProt: P18206 |
| Catalog # | MBS154475 |
| Price | $375 |
| Order / More Info | Vinculin Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Burridge K, Fath K, Kelly T, et al. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol.1988; 4:487-525. 2. Gilmore AP, Jackson P, Waites GT, et al. Further characterization of the talin-binding site in the cytoskeletal protein vinculin. J. Cell Sci. 1992; 103:719-31. 3. Deakin NO, Ballestrem C, and Turner CE. Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One 2012; 7:e37990. 4. Goldmann WH, Auernheimer V, Thievessen I, et al. Vinculin, cell mechanics and tumour cell invasion. Cell Biol. Int. 2013; Feb 1. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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