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Antigenic Specificity | NOD3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against an 18 amino acid peptide near the center of human NOD3. |
Other Names | [Nucleotide-binding oligomerization domain containing 3, NLRC3, CLR16.2] |
Gene, Accession # | [NOD3], Gene ID: 197358, NCBI: EAW85351 |
Catalog # | MBS9414246 |
Price | $320 |
Order / More Info | NOD3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |