TP/ECGF1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityTP/ECGF1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL, 0.2 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionRabbit polyclonal to TP/ECGF1. Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate (1). This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function (2,3). Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis (4,5). Alternatively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment (1,5). The use of thymidine phospho
ImmunogenImmunogen: A Fusion protein of human TP/ECGF1
Other Names[TYMP; TYMP; ECGF1; MNGIE; PDECGF; TP; hPD-ECGF;], [TYMP; TYMP; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF; ECGF1; TP; PD-ECGF]
Gene, Accession #Gene ID: 1890, NCBI: NP_001107227.1, UniProt: P19971
Catalog #MBS125669
Price$275, $430
Order / More InfoTP/ECGF1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Rooseboom, M. et al. (2004) Pharmacol Rev 56, 53-102. 2. Moghaddam, A. and Bicknell, R. (1992) Biochemistry 31, 12141-6. 3. Furukawa, T. et al. (1992) Nature 356, 668. 4. Toi, M. et al. (2005) Lancet Oncol 6, 158-66. 5. Liekens, S. et al. (2007) Biochem Pharmacol 74, 1555-67.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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