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Antigenic Specificity | SMAD6 |
Clone | [5H3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. |
Immunogen | Immunogen: Purified recombinant fragment of human SMAD6 expressed in E. Coli. |
Other Names | [MADH6; MADH7; HsT17432; SMAD6] |
Gene, Accession # | [SMAD6], Gene ID: 4091, NCBI: O43541.2, UniProt: O43541 |
Catalog # | MBS8538675 |
Price | $280 |
Order / More Info | SMAD6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |