Human ADAMTS4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human ADAMTS4 |
| Clone | [10D5] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Neutr |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs 4), also known as aggrecanase1, is a member of the family of secreted zinc proteases with a multidomain structure. The protein precursors consist of a signal peptide and the following domains: pro, catalytic, disintegrin-like, TS type 1 motif, cysteine-rich, and spacer. It is the only ADAMTS identified that has one TS type I motif. It is an active protease effectively cleaving alpha2-macroglobulin and aggrecan at multiple sites, and is inhibited by TIMP3 with inhibition constants in subnanomolar range. It receives great attention due to the elevation in its mRNA level after treatment with Interleukin1. However, in a mouse model of osteoarthritis, ADAMTS4 knockout mice d |
| Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human ADAMTS-4 recombinant protein). The IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography. |
| Other Names | [ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4], [ADAMTS4; ADAMTS4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4] |
| Gene, Accession # | [ADAMTS4], Gene ID: 9507, NCBI: NP_005090.3, UniProt: O75173 |
| Catalog # | MBS690429 |
| Price | $475 |
| Order / More Info | Human ADAMTS4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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