Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) antibody, protein, ELISA kits.
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| Antigenic Specificity | Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) |
| Clone | [LAG3/3261] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | purified |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: LAG-3 (also called CD223) is a high affinity MHC class II ligand present on the surface of CD4+CD8+ T cells and NK cell, with shared homology in structure to CD4 molecules. It has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian, parasitic, and bacterial proteins that may influence a conserved biological function. LAG-3+CD4+CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro. LAG-3 inhibits CD4-dependent T cell function via its cytoplasmic domain. LAG-3 Lys-468 within a conserved 'KIEELE' motif is essential for interaction with downstream signaling molecules. Furthermore, as a checkpoint inhibitor target, it may be superior to CTLA-4 an |
| Immunogen | Immunogen: Recombinant full-length human LAG3 protein |
| Other Names | [CD223; FDC protein; LAG-3] |
| Gene, Accession # | [LAG-3], Gene ID: 3902, NCBI: P18627.5, UniProt: P18627 |
| Catalog # | MBS4381061 |
| Price | $190, $340, $340 |
| Order / More Info | Lymphocyte Activation Gene 3 (LAG-3) (Negative Checkpoint Regulator) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Andrews LP., et al. Immunol Rev. 2017 Mar;276(1):80-96. doi: 10.1111/imr.12519. 2. Demeure, C.E., et al. 2001. Eur. J. Cancer 37: 1709-171 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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