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Antigenic Specificity | TIMELESS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promote |
Immunogen | Immunogen: Recombinant Human Protein timeless homolog protein (1004-1131AA) |
Other Names | [Protein timeless homolog; hTIM; TIMELESS] |
Gene, Accession # | [TIMELESS], Gene ID: 8914, NCBI: NP_001317224.1, UniProt: Q9UNS1 |
Catalog # | MBS7108715 |
Price | $160, $235 |
Order / More Info | TIMELESS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |