LEP Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | LEP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Leptin is a 16 kDa adipocytederived hormone that relays the status of the body's energy reserves to the hypothalamus, resulting in the suppression of appetite and modulation of energy expenditure (1,2). Leptin functions as a pleiotropic cytokine with multiple roles in immune function and reproduction (14). There are at least five isoforms of the leptin receptor, but only OBRb is signaling competent (1,2). OBRb is expressed on a number of cells, including T cells, B cells, keratinocytes, and others (16). Leptin/OBRb interactions induce Jak2, PI3K, Erk1/2, and Stat3 activation (1,2). OBRb is often highly expressed in many tumor types, including breast, pancreatic, and Tumor Initiating Stem Cells (TISCS), providing a potential mechanistic link |
| Immunogen | Immunogen: A synthetic peptide of human LEP |
| Other Names | [LEP; LEP; OB; OBS; Leptin; Obese protein; Obesity factor;], [LEP; LEP; OB; OBS; LEPD; OB; OBS] |
| Gene, Accession # | Gene ID: 3952, NCBI: NP_000221.1, UniProt: P41159 |
| Catalog # | MBS126282 |
| Price | $200, $275, $430 |
| Order / More Info | LEP Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Faggioni, R. et al. (2001) FASEB J 15, 256571. 2. Park, J. et al. (2011) Endocr Rev 32, 55070. 3. Mancuso, P. et al. (2011) J Immunol 186, 108190. 4. Hausman, G.J. and Barb, C.R. (2010) Endocr Dev 19, 3144 5. Kanda, N. and Watanabe, S. (2008) Endocrinology 149, 518998. 6. Tanaka, M. et al. (2011) J Neurosci 31, 837380. 7. Feldman, D.E. et al. (2012) Proc Natl Acad Sci U S A 109, 82934. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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