PDK1 (Tyr-9), phospho-specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PDK1 (Tyr-9), phospho-specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose, then affinity purified using phospho- PDK1 (Tyr-9) peptide. The purified antibody detects a 65 kDa* protein corresponding to the apparent molecular mass of PDK1 on SDS-PAGE immunoblots of human A431 cells treated with EGF, IGF-1, or pervanadate, but not in untreated cells. PDK1 (Tyr-9) reactivity was also observed in adult mouse brain. 3-Phosphoinositide-dependent kinase 1 (PDK1), also known as PKB kinase, was identified as the activator of the survival kinase Akt/PKB. Several important substrates of PDK1 include p70S6 kinase, PKAs, PKCs, SGKs, RSKs, and PAKs. PDK1 is a member of the AGC superfamily of serine/threonine kinases. Through the phosphorylation of downstream |
| Immunogen | Immunogen: Phospho-PDK1 (Tyr-9) synthetic peptide (coupled to carrier protein) corresponds to amino acids surrounding tyrosine 9 in human PDK1. This sequence is highly conserved in rat and mouse PDK1. |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS472050 |
| Price | $385 |
| Order / More Info | PDK1 (Tyr-9), phospho-specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Park, J. et al. (2001) J Biol. Chem. 276(40):37459.• Taniyama, Y. et al. (2003) Mol Cell. Biol. 23(22):8019.• Scheid, M.P. et al. (2005) Mol. Cell. Biol. 25(6):2347.• Block, K. et al. (2008) J. Biol. Chem. 35:24061. (WB: Rat mesangial cells) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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