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Antigenic Specificity | MAP2K3 (Phospho-Thr222) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of MAP2K3 only when phosphorylated at threonine 222. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Derijard B., Science 267:682-685(1995).Morigu |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of threonine 222(A-K-T(p)-M-D) derived from Human MAP2K3. |
Other Names | [MAP2K3; MAPKK 3; MEK3; MP2K3; PRKMK3] |
Gene, Accession # | [MAP2K3], Gene ID: 5606, NCBI: NP_002747.2, UniProt: P46734 |
Catalog # | MBS9401095 |
Price | $200, $255 |
Order / More Info | MAP2K3 (Phospho-Thr222) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |