TRADD Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | TRADD |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: TRADD antibody detects endogenous levels of total TRADD. Description: Apoptosis mediated by death factors like FasL and TNF-alpha involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) containing adaptor proteins FADD (Fas associated death domain) (2, 3) and TRADD (TNF-R1 associated death domain) (4). In addition to its carboxy-terminal DD, FADD contains an amino-terminal death effector domain (DED) that binds to DEDs found on caspase-8 which leads to activation of this initiator caspase (5, 6). Caspase-8 subsequently activates downstream effector caspases, like caspase-3, resulting in the c |
| Immunogen | Immunogen: A synthesized peptide derived from human TRADD Subcellular Location: Cytoplasm > Cytoskeleton. Tissue Specificity: Found in all examined tissues. Predicted Cross Reactivity: Pig, Bovine, Sheep Similarity: Pig (80%), Bovine (80%), Sheep (80%) |
| Other Names | [9130005N23Rik; AA930854; TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein] |
| Gene, Accession # | [TRADD], Gene ID: 8717, NCBI: NP_001310481.1, UniProt: Q15628 |
| Catalog # | MBS9606938 |
| Price | $240, $280 |
| Order / More Info | TRADD Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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