Edit |   |
---|---|
Antigenic Specificity | APAF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, bovine, rabbit, monkey, horse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 200 ug/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | During apoptosis, Apaf-1 binds to cytochrome c, a reaction that requires dATP, and this leads to the formation of a large multimeric complex. The complex recruits pro-caspase-9, and activates caspase-9. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf-1 is ubiquitously expressed in human tissues. |
Immunogen | Immunogen: APAF1 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 1161 of human Apaf-1 as the immunogen. |
Other Names | [Rabbit APAF1; APAF1; APAF1; APAF 1; APAF1; DKFZp781B1145; CED4; KIAA0413; APAF-1; APAF-1; APAF 1] |
Gene, Accession # | [APAF1], Gene ID: 317, UniProt: O14727 |
Catalog # | MBS5311124 |
Price | $475 |
Order / More Info | APAF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |