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Antigenic Specificity | KDEL |
Clone | [1F2] |
Host Species | Mouse |
Reactive Species | human; mouse; rat |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects KDEL tagged proteins. The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. |
Immunogen | Immunogen: KDEL peptide (C-AVKDEL-COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA). Conjugate: Unconjugated. Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
Other Names | n/a |
Gene, Accession # | [KDEL] |
Catalog # | MBS809060 |
Price | $390 |
Order / More Info | KDEL Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610. 2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438. |