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Antigenic Specificity | ROS1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | Arabidopsis thaliana |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed: 25240767). Generates 3'-phosphor-alpha, beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate (PubMed: 25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation mod |
Immunogen | Immunogen: Recombinant Arabidopsis thaliana Protein ROS1 protein (1-320AA) |
Other Names | [Protein ROS1; DEMETER-like protein 1; Repressor of silencing 1; ROS1; DML1; At2g36490; F1O11.12] |
Gene, Accession # | [ROS1], Gene ID: 818224, NCBI: NP_181190.3, UniProt: Q9SJQ6 |
Catalog # | MBS7051265 |
Price | $160, $235 |
Order / More Info | ROS1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |