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Antigenic Specificity | PSENEN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcri |
Immunogen | Immunogen: A synthetic peptide of human PSENEN (NP 758844.1). |
Other Names | [gamma-secretase subunit PEN-2; Gamma-secretase subunit PEN-2; gamma-secretase subunit PEN-2; presenilin enhancer, gamma-secretase subunit; Presenilin enhancer protein 2] |
Gene, Accession # | [PSENEN], Gene ID: 55851, NCBI: NP_758844, UniProt: Q9NZ42 |
Catalog # | MBS8571206 |
Price | $280 |
Order / More Info | PSENEN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |