CD81/TAPA-1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD81/TAPA-1 |
| Clone | [1.3.3.22] |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat. |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
| Concentration | n/a |
| Applications | Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a protein of 26kDa, identified as CD81 (Workshop VI; Code CD81.1)). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on dif |
| Immunogen | Immunogen: B-Cell line derived from a Burkitt lymphoma Cellular Localization: Cell Surface |
| Other Names | [CD81; Target of the antiproliferative 1 (TAPA-1); Tetraspanin-28; Tspan-28] |
| Gene, Accession # | [CD81], Gene ID: 975, NCBI: NP_001284578.1, UniProt: P60033 |
| Catalog # | MBS4380374 |
| Price | $190, $340, $340 |
| Order / More Info | CD81/TAPA-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kishimoto T et al. eds. Leukocyte Typing VI, p187-189, Garland Publishing, New York, 1997. Takahashi S et al. TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol 1990, 145(7):2207-2213. Mannion BA et al. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin i eta i eta /- (CD49d/CD29). J Immunol 1996, 157(5):2039-2047. Sato S et al. Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. J Immunol 1997, 159(7):3278-3287. Horvath G et al. CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. J Biol Chem 1998, 273(46):30537-30543. Todd SC et al. CD81 expressed on human thymocytes mediates integrin activation and interleukin 2-dependent proliferation. J Exp Med 1996, 184(5):2055-2060. Levy S et al. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu Rev Immunol 1998, 16:89-109. Pileri P et al. Binding of hepatitis C virus to CD81. Science 1998, 282:938-941. Schlossman SF et al. eds. Leukocyte Typing V, Oxford University Press, Oxford, 1995. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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