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Antigenic Specificity | MAGED1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msx homeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptional activation of the p65 subunit of NF-kappaB, via the XIAP-Tak1-Tab1 complex. (20100 |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [MAGED1; DLXIN-1; NRAGE], [MAGED1; MAGED1; NRAGE; DLXIN-1; NRAGE] |
Gene, Accession # | [MAGED1], Gene ID: 9500, NCBI: Q9Y5V3.3, UniProt: Q9Y5V3 |
Catalog # | MBS127359 |
Price | $200, $275, $430 |
Order / More Info | MAGED1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |