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Antigenic Specificity | DDIT4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.5 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total DDIT4 protein. REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Full length fusion protein |
Other Names | [Dig2; REDD1; REDD-1] |
Gene, Accession # | [DDIT4], Gene ID: 54541, NCBI: NP_061931.1, UniProt: Q9NX09 |
Catalog # | MBS9406713 |
Price | $255 |
Order / More Info | DDIT4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |