NEDD4-2 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | NEDD4-2 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed: 25631046). Plays a role in dendrite formation by melanocytes (PubMed: 23999003). |
| Immunogen | Immunogen: A synthesized peptide derived from human NEDD4-2. Subcellular Localization: Cytoplasm. May be recruited to exosomes by NDFIP1. Tissue Specificity: Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed: 14615060, PubMed: 15496141, PubMed: 19664597). Expressed in melanocytes (PubMed: 23999003). |
| Other Names | [E3 ubiquitin-protein ligase NEDD4-like; 6.3.2.-; NEDD4.2; Nedd4-2; NEDD4L; KIAA0439; NEDL3], [NEDD4L] |
| Gene, Accession # | [NEDD4-2], Gene ID: 23327, NCBI: NP_001138436.1, UniProt: Q96PU5 |
| Catalog # | MBS179701 |
| Price | $160, $340, $340 |
| Order / More Info | NEDD4-2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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