SQSTM1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | SQSTM1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy (1-4). It was first identified as a protein that binds to the SH2 domain of p56Lck (5), and independently found to interact with PKC zeta (6, 7). SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome (8). Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-kappaB pathway (9). Protein aggregates formed by SQSTM1 can be degraded by the autophagosome (4, 10, 11). SQSTM1 binds autophagosomal membrane protein LC3/Atg8, bringing |
| Immunogen | Immunogen: Recombinant protein of human SQSTM1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [SQSTM1; A170; OSIL; PDB3; ZIP3; p60; p62; p62B] |
| Gene, Accession # | [SQSTM1], Gene ID: 8878, NCBI: NP_001135770.1, UniProt: Q13501 |
| Catalog # | MBS8504383 |
| Price | $310 |
| Order / More Info | SQSTM1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kirkin, V. et al. (2009) Mol Cell 34, 259-69. 2. Seibenhener, M.L. et al. (2007) FEBS Lett 581, 175-9. 3. Komatsu, M. et al. (2010) Nat Cell Biol 12, 213-23. 4. Bjorkoy, G. et al. (2006) Autophagy 2, 138-9. 5. Joung, I. et al. (1996) Proc Natl Acad Sci USA 93, 5991-5. 6. Sanchez, P. et al. (1998) Mol Cell Biol 18, 3069-80. 7. Puls, A. et al. (1997) Proc Natl Acad Sci USA 94, 6191-6. 8. Vadlamudi, R.K. et al. (1996) J Biol Chem 271, 20235-7. 9. Wooten, M.W. et al. (2005) J Biol Chem 280, 35625-9. 10. Bjorkoy, G. et al. (2005) J Cell Biol 171, 603-14. 11. Komatsu, M. et al. (2007) Cell 131, 1149-63. 12. Pankiv, S. et al. (2007) J Biol Chem 282, 24131-45. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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