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Antigenic Specificity | ErbB2, phosphorylated |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human ErbB2 when phosphorylated at tyrosine 1248. Species Crossreactivity: mouse, rat. The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. ErbB-2 overexpression is also observed in ovarian, gastric, s |
Immunogen | Immunogen: Synthetic phosphopeptide corresponding to human HER2 around the phosphorylation site of tyrosine1248 (P-E-YP-L-G). |
Other Names | ErbB2, phosphorylated (Tyr1248) (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL) |
Gene, Accession # | Gene ID: 2064, UniProt: Q9NP09 |
Catalog # | MBS625790 |
Price | $445 |
Order / More Info | ErbB2, phosphorylated Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |