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Antigenic Specificity | TRIP10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP 004231.1). |
Other Names | [STP; CIP4; HSTP; STOT; TRIP-10] |
Gene, Accession # | [TRIP10], Gene ID: 9322, NCBI: Q15642.3, UniProt: Q15642 |
Catalog # | MBS8546532 |
Price | $280 |
Order / More Info | TRIP10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |