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Antigenic Specificity | INS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.9 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total INS protein. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. |
Immunogen | Immunogen: Synthetic peptide of human INS |
Other Names | [IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10] |
Gene, Accession # | [INS], Gene ID: 3630, NCBI: NP_000198.1, UniProt: P01308 |
Catalog # | MBS9415760 |
Price | $255 |
Order / More Info | INS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |