Edit |   |
---|---|
Antigenic Specificity | Human CD152-Fab |
Clone | [ANC152.2/8H5] |
Host Species | Mouse |
Reactive Species | human, porcine, cow, cat, dog |
Isotype | IgG1k |
Format | unconjugated |
Size | 0.1 mg |
Concentration | 1.0 mg/ml |
Applications | Flow Cytometry (FC/FACS), ELISA (EIA), FX, Blocking |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Information: Human CD152 (CTLA-4) is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Antibody ANC152.2 reacts with CTLA-4 expressed on activated T cells. ANC152.2 binds to CD152 present on activated T cells, and blocks binding of recombinant CD152 (CTLA-4) fusion protein to CD80/CD86 receptors. |
Immunogen | Immunogen: Stimulated human PBL's and human CD152 Ig fusion protein |
Other Names | n/a |
Gene, Accession # | [CD152] |
Catalog # | MBS666017 |
Price | $1020 |
Order / More Info | Human CD152-Fab Antibody from MYBIOSOURCE INC. |
Product Specific References | T. Lindsten, et al, (1993) J Immunol 151: 3489-3499. T.L. Walunas, et al, (1994) Immunity 1:405-413. N.J. Karandikar, et al, (1996) J Exp Med 184: 783-788. A. Kitani, et al, (2000) J Immunol 165: 691-702. |