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Antigenic Specificity | SHIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total SHIP protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JN |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human SHIP. |
Other Names | [INPP5D; SH2-containing inositol 5-phosphatase] |
Gene, Accession # | [SHIP], Gene ID: 3635, NCBI: NP_001017915.1, UniProt: Q92835 |
Catalog # | MBS9403617 |
Price | $200, $255 |
Order / More Info | SHIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |