DDIT3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DDIT3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CHOP was identified as a C/EBPhomologous protein that inhibits C/EBP and LAP in a dominant-negative manner (1). CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lalpha expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2alpha thereby stimulating protein synthesis. Ero1-Lalpha promotes oxidative stress inside the endoplasmic reticulum (ER) (4). The role of CHOP in the programmed cell death of ER-st |
| Immunogen | Immunogen: Fusion protein of human DDIT3 |
| Other Names | [DDIT3; CHOP; CEBPZ; CHOP; CHOP10; GADD153; MGC4154;], [DDIT3; DDIT3; CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; CHOP; CHOP10; GADD153; DDIT-3; CHOP; CHOP-10] |
| Gene, Accession # | Gene ID: 1649, NCBI: NP_001181982.1, UniProt: P35638 |
| Catalog # | MBS125032 |
| Price | $200, $275, $430 |
| Order / More Info | DDIT3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Ron, D. and Habener, J.F. (1992) Genes Dev 6, 439-53. 2. Barone, M.V. et al. (1994) Genes Dev 8, 453-64. 3. Zinszner, H. et al. (1998) Genes Dev 12, 982-95. 4. Marciniak, S.J. et al. (2004) Genes Dev 18, 3066-77. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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