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Antigenic Specificity | MTAP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MTAP antibody detects endogenous levels of total MTAP. Description: MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5'-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1, 2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form c |
Immunogen | Immunogen: A synthesized peptide derived from human MTAP Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed. Predicted Cross Reactivity: Zebrafish, Bovine, Sheep, Rabbit, Chicken, Xenopus Similarity: Zebrafish (100%), Bovine (100%), Sheep (100%), Rabbit (100%), Chicken (100%), Xenopus (100%) |
Other Names | [5' methylthioadenosine phosphorylase; 5''-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL 249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAP_HUMAN; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase] |
Gene, Accession # | [MTAP], Gene ID: 4507, NCBI: NP_002442.2, UniProt: Q13126 |
Catalog # | MBS9606856 |
Price | $240, $280 |
Order / More Info | MTAP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |