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Antigenic Specificity | DPPA3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not co |
Immunogen | Immunogen: Recombinant Human Developmental pluripotency-associated protein 3 protein (1-159AA) |
Other Names | [Developmental pluripotency-associated protein 3; Stella-related protein; DPPA3; STELLAR] |
Gene, Accession # | [DPPA3], Gene ID: 359787, NCBI: NP_954980.1, UniProt: Q6W0C5 |
Catalog # | MBS7107335 |
Price | $160, $235 |
Order / More Info | DPPA3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |