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Antigenic Specificity | NRF1 |
Clone | [NRF1/2608] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxi |
Immunogen | Immunogen: Recombinant full-length human NRF1 protein |
Other Names | [alpha pal; Alpha palindromic-binding protein; Alpha-pal; locus control region factor 1; NFE2 related factor 1; Nuclear respiratory factor 1 (NFR-1)] |
Gene, Accession # | [NRF1], Gene ID: 4899, NCBI: NP_001035199.1, UniProt: Q16656 |
Catalog # | MBS4381126 |
Price | $190, $340, $340 |
Order / More Info | NRF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Sakamoto, H, et al. Clinical Cancer Research U.S. National Library of Medicine, Aug. 2001 |