NLK Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-NLK antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | NLK |
| Clone | [1146CT24.2.1] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Purified His-tagged NLK protein was used to produced this monoclonal antibody. Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase NLK; Nemo-like kinase; Protein LAK1; NLK; LAK1 {ECO:0000312|EMBL:AAD560131}] |
| Gene, Accession # | [NLK], Gene ID: 51701, NCBI: NP_057315.3, UniProt: Q9UBE8 |
| Catalog # | MBS9200543 |
| Price | $165, $370 |
| Order / More Info | NLK Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kehrer-Sawatzki H., et al. Gene 251:63-71(2000). Wang C., et al. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. Ota T., et al. Nat. Genet. 36:40-45(2004). Ishitani T., et al. Mol. Cell. Biol. 23:131-139(2003). Ohkawara B., et al. Genes Dev. 18:381-386(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies