MLXIP Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MLXIP |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human. predicted: mouse (95%) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1). MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2). MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3). |
| Immunogen | Immunogen: MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP. Buffer: MLXIP Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [MLXIP; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; MLX interacting protein], [MLXIP; MLXIP; MIR; MONDOA; bHLHe36; bHLHe36] |
| Gene, Accession # | [MLXIP], Gene ID: 22877, NCBI: NP_055753, UniProt: Q9HAP2 |
| Catalog # | MBS154454 |
| Price | $375 |
| Order / More Info | MLXIP Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Billin AN, Eilers AL, Coulter KL, et al. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol. Cell Biol. 2000; 20:8845-54. 2. Kaadige MR, Yang J, Wilde BR, et al. MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol. Cell Biol. 2015; 35:101-10. 3. Carroll PA, Diolaiti D, McFerrin L, et al. Deregulated Myc requires ModoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015; 27:271-85. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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