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Antigenic Specificity | SIGIRR - C-terminal region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | cow, dog, guinea pig, horse, human, mouse, porcine, rat, zebrafish |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.Target Description: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP. |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR |
Other Names | [SIGIRR; Single Ig IL-1-related receptor; single Ig IL-1-related receptor; single Ig and TIR domain containing; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8] |
Gene, Accession # | [SIGIRR], Gene ID: 59307, NCBI: CAG33619, UniProt: Q6IA17 |
Catalog # | MBS3209563 |
Price | $335 |
Order / More Info | SIGIRR - C-terminal region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |