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Antigenic Specificity | Phospho-eIF4B (Ser497) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, ratpredicted: bovine, horse, sheep, rabbit, dog |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-eIF4B (Ser497) Antibody detects endogenous levels of eIF4B only when phosphorylated at Ser497. Description: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.Post Translational Modifications: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.Subunit Structure: Self-associates and interacts with EIF3 p170 subunit. |
Immunogen | Immunogen: A synthesized peptide derived from human eIF4B around the phosphorylation site of Ser497. |
Other Names | [2310046H11Rik; AL024095; C85189; EIF 4B; eIF-4B; EIF4B; Eukaryotic initiation factor 4B; Eukaryotic translation initiation factor 4B; IF4B_HUMAN; PRO1843] |
Gene, Accession # | [eIF4B], Gene ID: 1975, NCBI: NP_001408.2, UniProt: P23588 |
Catalog # | MBS9610630 |
Price | $225, $280, $340 |
Order / More Info | Phospho-eIF4B (Ser497) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |