MCL1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-MCL1 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | MCL1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mcl-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway (1). Similar to other Bcl-2 family members, Mcl-1 localizes to the mitochondria (2), interacts with and antagonizes pro-apoptotic Bcl-2 family members (3), and inhibits apoptosis induced by a number of cytotoxic stimuli (4). Mcl-1 differs from its other family members in its regulation at both the transcriptional and post-translational level. First, Mcl-1 has an extended amino-terminal PEST region, which is responsible for its relatively short half-life (1, 2). Second, unlike other family members, Mcl-1 is rapidly transcribed via a PI3K/Akt |
| Immunogen | Immunogen: Fusion protein of human MCL1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MCL1; BCL2L3; EAT; MCL1L; MCL1S; MGC104264; MGC1839; Mcl-1; TM] |
| Gene, Accession # | [MCL1], Gene ID: 4170, NCBI: NP_001184249.1, UniProt: Q07820 |
| Catalog # | MBS8527329 |
| Price | $310 |
| Order / More Info | MCL1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kozopas, K.M. et al. (1993) Proc Natl Acad Sci USA 90, 3516-20. 2. Yang, T. et al. (1995) J Cell Biol 128, 1173-84. 3. Sato, T. et al. (1994) Proc Natl Acad Sci USA 91, 9238-42. 4. Zhou, P. et al. (1997) Blood 89, 630-43. 5. Wang, J.M. et al. (1999) Mol Cell Biol 19, 6195-206. 6. Jourdan, M. et al. (2003) Oncogene 22, 2950-9. 7. Chao, J.R. et al. (1998) Mol Cell Biol 18, 4883-98. 8. Domina, A.M. et al. (2000) J Biol Chem 275, 21688-94. 9. Inoshita, S. et al. (2002) J Biol Chem 277, 43730-4. 10. Domina, A.M. et al. (2004) Oncogene 23, 5301-15. 11. Maurer, U. et al. (2006) Mol Cell 21, 749-60. 12. Rinkenberger, J.L. et al. (2000) Genes Dev 14, 23-7. 13. Opferman, J.T. et al. (2003) Nature 426, 671-6. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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