APP/beta-Amyloid Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | APP/beta-Amyloid |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Amyloid beta (Abeta) precursor protein (APP) is a 100-140 kDatransmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Abeta), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Abeta fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M-phase (4). APP phosphorylated at Thr668 exists in adult rat brain and |
| Immunogen | Immunogen: N term-peptide of human APP Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN2; amyloidP; Amyloid beta A4 protein; A4; Beta Amyloid] |
| Gene, Accession # | [APP], Gene ID: 351, NCBI: NP_000475.1, UniProt: P05067 |
| Catalog # | MBS8502662 |
| Price | $310 |
| Order / More Info | APP/beta-Amyloid Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Selkoe, D.J. (1996) J BiolChem 271, 18295-8. 2. Caporaso, G.L. et al. (1992) ProcNatlAcadSci USA 89, 3055-9. 3. Hung, A.Y. and Selkoe, D.J. (1994) EMBO J 13, 534-42. 4. Suzuki, T. et al. (1994) EMBO J 13, 1114-22. 5. Ando, K. et al. (1999) J Neurosci 19, 4421-7. 6. Iijima, K. et al. (2000) J Neurochem 75, 1085-91. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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