IL10 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-IL10 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | IL10 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages (1, 2). IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1). Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 (1, 3). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFN gamma receptor, by upregulating expression of SOCS-1 (1, 3). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (4, 5). IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy (1). In contrast, increased IL-10 l |
| Immunogen | Immunogen: Recombinant protein of human IL10 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [IL10; CSIF; GVHDS; IL-10; IL10A; TGIF; Interleukin-10; Cytokine synthesis inhibitory factor] |
| Gene, Accession # | [IL10], Gene ID: 3586, NCBI: NP_000563.1, UniProt: P22301 |
| Catalog # | MBS8501181 |
| Price | $310 |
| Order / More Info | IL10 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Pestka, S. et al. (2004) Immunol Rev 202, 8-32. 2. Akuffo, H. et al. (1999) Clin Exp Immunol 117, 529-34. 3. O'Shea, J.J. and Murray, P.J. (2008) Immunity 28, 477-87. 4. Akdis, C.A. and Blaser, K. (2001) Immunology 103, 131-6. 5. Akdis, C.A. et al. (2000) FASEB J 14, 1666-8. 6. Von Stebut, E. (2000) Eur J Dermatol 17, 115-22. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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