VCL Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | VCL |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1-4). Three structural vinculin domains include an amino-terminal head, a short, flexible proline-rich region and a carboxy-terminal tail (1). In the inactive state, the head and tail domains of vinculin interact to form a closed confirmation. The open and active form of vinculin translocates to focal adhesions where it is thought to be involved in anchoring F-actin to the membrane and regulation of cell migration (2). Phospholipid binding to the tail domain and subsequent phosphorylation of vinculin at Ser1033 and Ser1045 by PKC-alpha and Tyr100 and Tyr1065 by Src kinases weakens the head-tail interaction (5, 6). |
| Immunogen | Immunogen: Recombinant protein of human VCL Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MV; MVCL; CMD1W; CMH15] |
| Gene, Accession # | [VCL], Gene ID: 7414, NCBI: NP_003364.1, UniProt: P18206 |
| Catalog # | MBS8502751 |
| Price | $310 |
| Order / More Info | VCL Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Izard, T. et al. (2004) Nature 427, 171-5. 2. Humphries, J.D. et al. (2007) J Cell Biol 179, 1043-57. 3. Witt, S. et al. (2004) J Biol Chem 279, 31533-43. 4. Xu, W. et al. (1998) Development 125, 327-37. 5. Ziegler, W.H. et al. (2002) J Biol Chem 277, 7396-404. 6. Zhang, Z. et al. (2004) Mol Biol Cell 15, 4234-47. 7. Rodriguez Fernandez, J.L. et al. (1993) J Cell Biol 122, 1285-94. 8. Samuels, M. et al. (1993) J Cell Biol 121, 909-21. 9. Yang, H.J. et al. (2010) Cancer Invest 28, 127-34. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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