SIRT1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | SIRT1 |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human, monkey |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4. The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53.SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras. The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress.SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues, with high expr |
| Immunogen | Immunogen: Purified recombinant fragment of human SIRT1 expressed in E. Coli. |
| Other Names | [SIR2L1; SIRT1], [SIRT1; SIRT1; SIR2; SIR2L1; SIR2alpha; SIR2L1; hSIRT1; hSIR2; 75SirT1] |
| Gene, Accession # | [SIRT1], Gene ID: 23411, NCBI: NP_001135970.1, UniProt: Q96EB6 |
| Catalog # | MBS850730 |
| Price | $280 |
| Order / More Info | SIRT1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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