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Antigenic Specificity | Human Bid |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 100ug/200ul |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human Bid. Members of the Bcl-2 family are pro-or antiapoptotic proteins that process one or several of the Bcl-2 homology (BH) domains. Bid is a proapoptotic, BH3-domain-only member or BH3-only protein (BOP) of the Bcl-2 family. Bid is localized in the cytosolic fraction of living cells as an inactive precursor. Activation of Bid occurs upon its cleavage by caspase-8 in the Fas and TNF-beta apoptotic signaling pathways. Recent studies have suggested that Bid is also cleaved and activated by granzyme B, calpain and lysosomal extracts. Cleaved Bid translocates to mitochondria where it induces the release of cytochrome c from the intermembrane space of the mitochondria. The release of cytochrome c initiates apoptosis by activatin |
Immunogen | n/a |
Other Names | [BID; BH3-interacting domain death agonist; BH3-interacting domain death agonist; BH3 interacting domain death agonist; p22 BID; BID] |
Gene, Accession # | [Bid], Gene ID: 637, NCBI: CAG30275.1, UniProt: P55957 |
Catalog # | MBS4152612 |
Price | $445 |
Order / More Info | Human Bid Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |