Edit |   |
---|---|
Antigenic Specificity | Annexin A2 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed: 18799458, PubMed: 24808179, PubMed: 22848640). |
Immunogen | Immunogen: A synthesized peptide derived from human Annexin A2. Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. |
Other Names | [Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36; ANXA2; ANX2; ANX2L4; CAL1H; LPC2D], [ANXA2; ANXA2; P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270; ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV] |
Gene, Accession # | [ANXA2], Gene ID: 302, NCBI: NP_001002857.1, UniProt: P07355 |
Catalog # | MBS179478 |
Price | $160, $340, $340 |
Order / More Info | Annexin A2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |