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Antigenic Specificity | CD40 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD40 Ligand (CD40L), a member of the TNF superfamily of ligands, is expressed as either a membrane-bound or soluble homotrimer (1). Both membrane-bound and soluble forms of CD40L have biological activity (1,2). CD40L is expressed primarily on activated T cells; however, mast cells, basophils, and NK cells may also express CD40L (1). CD40L functions as an important T cell co-stimulatory molecule and enhances T-dependent B cell responses (1,2). CD40L binds CD40, which is a receptor expressed on B cells, dendritic cells, and macrophages (1). Binding of CD40L to CD40 leads to the recruitment of TRAF proteins (TRAFs 2,3,5, and 6) resulting in the activation of the JNK and NF-kappaB pathways (1,2). |
Immunogen | Immunogen: C term -peptide of human CD40 Calculated Molecular Weight: 31kDa |
Other Names | [CD40; Bp50; CDW40; MGC9013; TNFRSF5; p50], [CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5] |
Gene, Accession # | [CD40], Gene ID: 958, NCBI: P25942.1, UniProt: P25942 |
Catalog # | MBS125050 |
Price | $200, $275, $430 |
Order / More Info | CD40 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |