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Antigenic Specificity | NEUROD1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG (1,2). Neuronal activity results in CaMKII-mediated phosphorylation of NeuroD at Ser336, which is necessary for formation and growth of dendrites (3,4). NeuroD is also phosphorylated at Ser274 though the results are context dependent as phosphorylation by Erk stimulates NeuroD activity in pancreatic beta-cells while phosphorylation by GSK-3beta inhibits NeuroD in neurons (3). NeuroD is crucially important in both the pancreas and developing nervous system, and plays a large role in the development of the inner ear and mammalian retina (3). |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [NEUROD1; BETA2; BHF-1; NEUROD; bHLHa3], [NEUROD1; NEUROD1; BETA2; BHF-1; MODY6; NEUROD; bHLHa3; BHLHA3; NEUROD; NeuroD; NeuroD1; bHLHa3] |
Gene, Accession # | [NEUROD1], Gene ID: 4760, NCBI: Q13562.3, UniProt: Q13562 |
Catalog # | MBS126695 |
Price | $200, $275, $430 |
Order / More Info | NEUROD1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |