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Antigenic Specificity | Collagen IV |
Clone | [3G3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: No cross reactivity with other proteins. Description: Mouse IgG monoclonal antibody for Collagen IV detection. Tested with WB, IHC-P in Human.Background: COL4A1, also known as ICH or Collagen alpha-1 (IV), is a protein that in humans is encoded by the COL4A1 gene. It is mapped to 13q34. This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. COL4A1 binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. It is also a potential therapeutic candidate fo |
Immunogen | Immunogen: E Coli-derived human Collagen IV recombinant protein (Position: G1445-T1669). Human Collagen IV shares 97% amino acid (aa) sequence identity with mouse Collagen IV. |
Other Names | [Collagen alpha-1 (IV) chain; Arresten; COL4A1; Collagen, type IV, alpha 1] |
Gene, Accession # | [COL4A1], Gene ID: 1282, NCBI: NP_001290039.1, UniProt: P02462 |
Catalog # | MBS1752097 |
Price | $315 |
Order / More Info | Collagen IV Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Soininen R, Haka-Risku T, Prockop DJ, Tryggvason K (Jan 1988). Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. FEBS Lett 225 (1-2): 188-94. 2. Plaisier E, Gribouval O, Alamowitch S et al. (2007). COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N. Engl. J. Med. 357 (26): 2687-2695. 3. Wang, X., Harris, R. E., Bayston, L. J., Ashe, H. L. Type IV collagens regulate BMP signalling in Drosophila. Nature 455: 72-77, 2008. |