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Antigenic Specificity | Human Serine/threonine-protein kinase PAK 1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB an |
Immunogen | Immunogen: Recombinant human Serine/threonine-protein kinase PAK 1 protein(1-240aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-882 / sc-881 / sc-11394 / sc-48826 |
Other Names | [Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK1], [PAK1; PAK1; PAKalpha; PAK-1] |
Gene, Accession # | [PAK1], Gene ID: 5058, NCBI: NP_001122092.1, UniProt: Q13153 |
Catalog # | MBS1499509 |
Price | $120, $160 |
Order / More Info | Human Serine/threonine-protein kinase PAK 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |