Edit |   |
---|---|
Antigenic Specificity | SPPL2A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simia |
Immunogen | Immunogen: Recombinant human Signal peptide peptidase-like 2A protein |
Other Names | [Signal peptide peptidase-like 2A1; Intramembrane protease 31; SPPL2A1] |
Gene, Accession # | [SPPL2A], Gene ID: 84888, NCBI: NP_116191.2, UniProt: Q8TCT8 |
Catalog # | MBS7000501 |
Price | $160, $235 |
Order / More Info | SPPL2A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |