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Antigenic Specificity | MAP3K12, 828-859 |
Clone | [473CT23.12.5] |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAP3K12 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 828-859 amino acids from human MAP3K12. This gene encodes a member of the serine/threonine proteinkinase family. This kinase contains a leucine-zipper domain and ispredominately expressed in neuronal cells. The phosphorylationstate of this kinase in synaptic terminals was shown to beregulated by membrane depolarization via calcineurin. This kinaseforms heterodimers with leucine zipper containing transcriptionfactors, such as cAMP responsive element binding protein (CREB) andMYC, and thus may play a regulatory role in PKA or retinoic acidinduced neuronal differentiation. Alternatively spliced transcriptva |
Immunogen | n/a |
Other Names | [Mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; Leucine-zipper protein kinase; ZPK; MAPK-upstream kinase; MUK; Mixed lineage kinase; MAP3K12; ZPK] |
Gene, Accession # | [MAP3K12], Gene ID: 7786, NCBI: NP_001180440.1, UniProt: Q12852 |
Catalog # | MBS9200446 |
Price | $370 |
Order / More Info | MAP3K12, 828-859 Antibody from MYBIOSOURCE INC. |
Product Specific References | Clague, J., et al. Mol. Carcinog. 49(2):183-189(2010) Robitaille, H., et al. J. Invest. Dermatol. 130(1):74-85(2010) Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009) : Daviau, A., et al. Cell. Signal. 21(4):577-587(2009) Mukhopadhyay, R., et al. Mol. Cell 32(3):371-382(2008) |