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Antigenic Specificity | PRKAR1A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PRKAR1A protein. The second messenger cyclic AMP (cAMP) activates cAMP-dependent protein kinase (PKA or cAPK) in mammalian cells and controls many cellular mechanisms such as gene transcription, ion transport, and protein phosphorylation (1). Inactive PKA is a heterotetramer composed of a regulatory subunit (R) dimer and a catalytic subunit (C) dimer. In this inactive state, the pseudosubstrate sequences on the R subunits block the active sites on the C subunits. Three C subunit isoforms (C-a, C-b, and C-g) and two families of regulatory subunits (RI and RII) with distinct cAMP binding properties have been identified. The two R families exist in two isoforms, a and b (RI-a, RI-b, RII-a, and RII |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human PRKAR1A. |
Other Names | [PRKAR1A; CAR; CNC; CNC1; DKFZp779L0468] |
Gene, Accession # | [PRKAR1A], Gene ID: 5573, NCBI: NP_001263218.1, UniProt: P10644 |
Catalog # | MBS9411391 |
Price | $255 |
Order / More Info | PRKAR1A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |